教員紹介 詳細

主な業績

原著論文・総説
1. Niwano Y, Kohzaki H, Shirato M, Shishido S, Nakamura K.: Metabolic fate of orally ingested proanthocyanidins through the digestive tract. Antioxidants (Basel), 12:17, 2023

2. Shirato M, Nakamura K, Tenkumo T, Niwano Y, Kanno T, Sasaki K, Lingström P, Örtengren U.: Inhibition of tooth demineralization caused by Streptococcus mutans biofilm via antimicrobial treatment using hydrogen peroxide photolysis. Clin Oral Investig, 27:739-750, 2023

3. Miyano R, Matsuo H, Mokudai T, Higo M, Nonaka K, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.: New nitrogen-compounds, penicidones E and F, produced by the fungal strain Oidiodendron sp. FKI-7498. Biosci Biotechnol Biochem, 87:38-44, 2022

4. Niwano Y, Kohzaki H, Shirato M, Shishido S, Nakamura K.: Putative mechanisms underlying the beneficial effects of polyphenols in murine models of metabolic disorders in relation to gut microbiota. Curr Issues Mol Biol, 44:1353-1375, 2022

5. Niwano Y, Kohzaki H, Shirato M, Shishido S, Nakamura K: Anti-osteoporotic mechanisms of polyphenols elucidated based on in vivo studies using ovariectomized animals. Antioxidants (Basel), 11:217, 2022

6. Tenkumo T, Aobulikasimu A, Asou Y, Shirato M, Shishido S, Kanno T, Niwano Y, Sasaki K, Nakamura K: Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals. Sci Rep, 10:8812, 2020

7. Nakamura K, Shirato M, Shishido S, Niwano Y, Kanno T, Sasaki K, Lingström P, Örtengren U: Reactions of dental pulp to hydrogen peroxide photolysis-based antimicrobial chemotherapy under ultraviolet-A irradiation in rats. J Photochem Photobiol B, Biology, 212:112042, 2020

8. Matsuo H, Hirose T, Mokudai T, Nonaka K, Niwano Y, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T: Absolute structure and anti-oxidative activity of chaetochiversin C isolated from fungal strain Neocosmospora sp. FKI-7792 by physicochemical screening. J Gen Appl Microbiol, 26:181-187, 2020. 2020

9. Miyano R, Matsuo H, Mokudai T, Noguchi Y, Higo M, Nonaka K, Niwano Y, Sunazuka T, Shiomi K, Takahashi Y, Ōmura S, Nakashima T: Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-7573. J Biosci Bioeng, 129:508-513, 2020

10. Matsuo H, Mokudai T, Higo M, Nonaka K, Nagano Y, Nagahama T, Niwano Y, Takahashi Y, Ōmura S, Nakashima T: Cipralphelin, a new anti-oxidative N-cinnamoyl tripeptide produced by the deep sea-derived fungal strain Penicillium brevicompactum FKJ-0123. J Antibiot, 72:775-778, 2019

11. Shirato M, Nakamura K, Tenkumo T, Kano Y, Ishiyama K, Kanno T, Sasaki K, Niwano Y, Matsuura H: Oral mucosal irritation potential of antimicrobial chemotherapy involving hydrogen peroxide photolysis with high-power laser irradiation for the treatment of periodontitis. J Photochem Photobiol B, Biology, 201:111633, 2019

12. Niwano Y, Iwasawa A, Tsubota K, Ayaki M, Negishi K: Protective effects of blue light-blocking shades on phototoxicity in human ocular surface cells. BMJ Open Ophthalmol, 4: e000217, 2019

13. Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, Örtengren U, Sasaki K, Niwano Y: Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation. Sci Rep, 9:4688, 2019

14. Ueda T, Ueda K, Ito K, Ogasawara K, Kanetaka H, Mokudai T, Niwano Y, Narushima T: Visible-light-responsive antibacterial activity of Au-incorporated TiO2 layers formed on Ti-(0-10)at%Au alloys by air oxidation. J Biomed Mater Res Part A, 107:991-1000, 2019

15. Nakamura K, Ankyu S, Nilsson F, Kanno T, Niwano Y, Vult von Steyern P, Örtengren U: Critical considerations on load-to-failure test for monolithic zirconia molar crowns. J Mech Behav Biomed Mater, 87:180-189, 2018

16. Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Örtengren U, Kanno T, Niwano Y, Egusa H: Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation. PloS one 13:e0203849, 2018

17. Miyano R, Matsuo H, Nonaka K, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T: Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537. J Biosci Bioeng, 126:661-666, 2018

18. Shishido S, Miyano R, Nakashima T, Matsuo H, Iwatsuki M, Nakamura K, Kanno T, Egusa H, Niwano Y: A novel pathway for the photooxidation of catechin in relation to its prooxidative activity. Sci Rep, 8:12888, 2018

19. Ankyu S, Nakamura K, Harada A, Inagaki R, Kastuda Y, Kanno T, Niwano Y, Örtengren U, Egusa H: Influence of microscale expansion and contraction caused by thermal and mechanical fatigue on retentive strength of CAD/CAM-generated resin-based composite crowns. J Mech Behav Biomed Mater, 86:89-97, 2018

20. Jin G, Asou Y, Ishiyama K, Okawa A, Kanno T, Niwano Y: Proanthocyanidin-rich grape seed extract modulates intestinal microbiota in ovariectomized mice. J Food Sci, 83(4):1149-1152, 2018

21. Kimura T, Tajima A, Inahashi Y, Iwatsuki M, Kasai H, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T: Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79. J Gen Appl Microbiol, 64(2):62-67, 2018

22. Sheng H, Ogawa T，Niwano Y，Sasaki K，Tachibana K: Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells. J Oral Pathol Med, 47(4):368-374, 2018

23. Jin G, Aobulikasimu A, Piao J, Aibibula Z, Koga D, Ochi H, Ishiyama K, Kanno T, Niwano Y, Okawa A, Asou Y: Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders. J Med Dent Sci, 62(2):45-50, 2018

24. Niwano Y, Konno K, Matayoshi T, Nakamura, K., Kanno, T., Sasaki, K.: Oral mucosal irritation study in hamster to evaluate a therapeutic apparatus using hydrogen peroxide photolysis for periodontitis treatment. Regul Toxicol Pharmacol, 90:206-213, 2017

25. Kanno T, Nakamura K, Ishiyama K, Yamada Y, Shirato M, Niwano Y, Kayaba C, Ikeda K, Takagi A, Yamaguchi T., Sasaki K: Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis in non-surgical treatment for moderate to severe periodontitis: a randomized clinical trial. Sci Rep, 7(1):12247, 2017

26. Shirato M, Nakamura K, Kanno T, Lingström P, Niwano Y, Örtengren U: Time-kill kinetic analysis of antimicrobial chemotherapy based on hydrogen peroxide photolysis against Streptococcus mutans biofilm. J Photochem Photobiol B, Biology, 173:434-440, 2017

27. Nakamura K, Shirato M, Kanno T, Lingström P, Örtengren U, Niwano Y: Photo-irradiated caffeic acid exhibits antimicrobial activity against Streptococcus mutans biofilms via hydroxyl radical formation. Sci Rep, 7(1):6353, 2017

28. Tominami K, Kanetaka H, Sasaki S, Mokudai T, Kaneko T, Niwano Y: Cold atmospheric plasma enhances osteoblast differentiation. PLoS One, 12(7):e0180507, 2017

29. Niwano Y, Tada M, Tsukada M: Antimicrobial intervention by photoirradiation of grape pomace extracts via hydroxyl radical generation. Front Physiol, 8:728, 2017

30. Sato E, Mori T, Mishima E, Suzuki A, Sugawara S, Kurasawa N, Saigusa D, Miura D, Morikawa-Ichinose T, Saito R, Oba-Yabana I, Oe Y, Kisu K, Naganuma E, Koizumi K, Mokudai T, Niwano Y, Kudo T, Suzuki C, Takahashi N, Sato H, Abe T, Niwa T, Ito S: Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease. Sci Rep, 6:36618, 2016

31. Sato H, Niwano Y, Nakamura K, Mokudai T, Ikai H, Kanno T, Egusa H: Efficacy and safety of a therapeutic apparatus using hydrogen peroxide photolysis to treat dental and periodontal infectious diseases. J Toxicol Sci, 41(6):793-799, 2016

32. Ishiyama K, Nakamura K, Kanno T, Niwano Y: Bactericidal action of photodynamic antimicrobial chemotherapy (PACT) with photosensitizers used as plaque-disclosing agents against experimental biofilm. Biocontrol Sci, 21(3):187-191, 2016

33. Nakamura K, Shirato M, Kanno T, Örtengren U, Lingström P, Niwano Y: Antimicrobial activity of hydroxyl radicals generated by hydrogen peroxide photolysis against Streptococcus mutans biofilm. Int J Antimicrob Agents, 48(4):373-380, 2016

34. Tsukada M, Sheng H, Kamachi T, Niwano Y: Microbicidal action of photoirradiated aqueous extracts from wine lees. J Food Sci Technol, 53(7):3020-3027, 2016

35. Ankyu S, Nakamura K, Harada A, Hong G, Kanno T, Niwano Y, Örtengren U, Egusa H: Fatigue analysis of computer-aided design/computer-aided manufacturing disilicate glass-ceramic. Eur J Oral Sci, 124(4):387-395, 2016

36. Tsukada M, Nakashima T, Kamachi T, Niwano Y: Prooxidative potential of photo-irradiated aqueous extracts of grape pomace, a recyclable resource from winemaking process. PLoS One, 11(6):e0158197, 2016

37. Tsukada M, Sheng H, Tada M, Mokudai T, Oizumi S, Kamachi T, Niwano Y: Bactericidal action of photo-irradiated aqueous extract from residue of crushed grape for wine preparation. Biocontrol Sci, 21(2):113-121, 2016

38. Nakamura K, Harada A, Ono M, Shibasaki H, Kanno T, Niwano Y, Milleding P, Örtengren U: Effect of low-temperature degradation on the mechanical and microstructural properties of tooth-colored 3Y-TZP ceramics. J Mech Behav Biomed Mater, 53:301-311, 2016

39. Tada M, Niwano Y, Kohno M: Generation mechanism of deferoxamine radical by tyrosine-tyrosinase reaction. Anal Sci, 31(9):911-916, 2015

40. Nakamura K, Katsuda Y, Ankyu S, Harada A, Tenkumo T, Kanno T, Niwano Y, Egusa H, Milleding P, Örtengren U: Cutting efficiency of diamond burs operated with electric high-speed dental handpiece on zirconia. Eur J Oral Sci, 123:375-380, 2015

41. Katsuda Y, Niwano Y, Nakashima T, Mokudai T, Nakamura K, Oizumi S, Kanno T, Kanetaka H, Egusa H: Cytoprotective effects of grape seed extract on human gingival fibroblasts in relation to its antioxidant potential. PLos ONE, 10(8): e0134704, 2015

42. Sheng H, Nakamura K, Kanno T, Sasaki K, Niwano Y : Bactericidal effect of photolysis of H2O2 in combination with sonolysis of water via hydroxyl radical generation. PLoS ONE, 10(7): e0132445, 2015

43. Nakamura K, Harada A, Kanno T, Inagaki R, Niwano Y, Milleding P, Örtengren U: The influence of low-temperature degradation and cyclic　loading on the fracture　resistance of monolithic zirconia molar crowns. J Mech Behav Biomed Mater, 47:49-56, 2015

44. Nakamura K, Ishiyama K, Sheng H, Ikai H, Kanno T, Niwano Y: Bactericidal activity and mechanism of photo-irradiated polyphenols against Gram-positive and -negative bacteria. J Agric Food Chem, 63(35):7707-7713, 2015

45. Harada A, Nakamura K, Kanno T, Inagaki R, Örtengren U, Niwano Y, Sasaki K, Egusa H: Fracture resistance of CAD/CAM-generated composite resin-based molar crowns. Eur J Oral Sci, 123(2):122-129, 2015

46. Nakamura K, Harada A, Inagaki R, Kanno T, Niwano Y, Milleding P, Örtengren U: Fracture resistance of monolithic zirconia molar crowns with reduced thickness. Acta Odontol Scand, 30:1-7, 2015

47. Mokudai T, Kanno T, Niwano Y: Postantifungal-like effect of sublethal treatment of Candida albicans with acid-electrolyzed water. Arch Oral Biol, 60(3):479-487, 2015

48. Mokudai T, Kanno T, Niwano Y: Involvement of reactive oxygen species in the cytotoxic effect of acid-electrolyzed water. J Toxicol Sci, 40(1):13-19, 2015

49. Toki T, Nakamura K, Kurauchi M, Kanno T, Katsuda Y, Ikai H, Hayashi E, Egusa H, Sasaki K, Niwano Y: Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity of photolysis of H2O2. J Biosci Bioeng, 119(3):358-362, 2015

50. Kurauchi M, Niwano Y, Shirato M, Kanno T, Nakamura K, Egusa H, Sasaki K: Cytoprotective effect of short-term pretreatment with proanthocyanidin on human gingival fibroblasts exposed to harsh environmental conditions. PLoS ONE, 9(11):e113403, 2014

51. Tada M, Kohno M, Niwano Y: Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with L-tyrosine and L-DOPA. BMC Biochem, 15:23, 2014

52. Tsuruya M, Niwano Y, Nakamura K, Kanno T, Egusa H, Sasaki K: Acceleration of proliferative response of mouse fibroblasts by short-time pretreatment with polyphenols. Appl Biochem Biotechnol, 174(6):2223-2235, 2014

53. Niwano Y, Kanno T, Iwasawa A, Ayaki M, Tsubota K: Blue light injures corneal epithelial cells in the mitotic phase in vitro. Br J Ophthalmol, 98(7):990-992, 2014

54. Sheng H, Nakamura K, Kanno T, Sasaki K, Niwano Y: Microbicidal activity of artificially generated hydroxyl radicals. Interface Oral Health Sci, 2014, pp203-215, 2014

55. Niwano Y, Iwasawa A, Ayaki M.: Ocular surface cytotoxicity and safety evaluation of tafluprost, a recently developed anti-glaucoma prostaglandin analogue. Ophthalmol Eye Dis, 6:5-12, 2014

56. Ikai H, Odashima Y, Kanno T, Nakamura K, Shirato M, Sasaki K, Niwano Y: In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide. PLoS ONE, 8(11):e81316, 2013

57. Nakahara T, Harada A, Yamada Y, Odashima Y, Nakamura K, Inagaki R, Kanno T, Sasaki K, Niwano Y: Influence of a new denture cleaning technique utilizing photolysis of H2O2 on mechanical properties and color stability of acrylic denture base resin. Dent Mater J, 32(4):529-536, 2013

58. Iwasawa A, Ayaki M, Niwano Y: Cell viability score (CVS) as a good indicator of critical concentration of benzalkonium chloride for toxicity in cultured ocular surface cell lines. Regul Toxicol Pharmacol, 66(2):177-183, 2013

59. Ikai H, Nakamura K, Kanno T, Shirato M, Meirelles L, Sasaki K, Niwano Y: Synergistic effect of proanthocyanidin on the bactericidal action of the photolysis of H2O2. Biocontrol Sci, 18(2):137-141, 2013

60. Nakamura K, Shirato M, Ikai H, Kanno T, Sasaki K, Kohno M, Niwano Y: Photo-irradiation of proanthocyanidin as a new disinfection technique via reactive oxygen species formation, PLoS ONE, 8(3):e60053, 2013

61. Oyamada A, Ikai H, Nakamura K, Hayashi E, Kanno T, Sasaki K, Niwano Y: In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation. Biocontrol Sci, 18(2):83-88, 2013

62. Niwano Y, Iwasawa A, Ayaki M: Safety evaluation of ophthalmic moxifloxacin, an antibiotic of the fourth-generation fluoroquinolone family. J Symptoms Signs, 2(6):468-474, 2013

63. Ayaki M, Iwasawa A, Niwano Y: Comparative assessment of the cytotoxicity of six anti-inflammatory eyedrops in four cultured ocular surface cell lines, as determined by cell viability scores. Clin Ophthalmol, 6:1879-1884, 2012

64. Nakamura K, Yamada Y, Ikai H, Kanno T, Sasaki K, Niwano Y: Bactericidal action of photo-irradiated gallic acid via reactive oxygen species formation. J Agric Food Chem, 60(40):10048-10054, 2012

65. Beppu F, Hosokawa M, Niwano Y, Miyashita K: Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice. Lipids Health Dis, 11(1):112, 2012

66. Mokudai T, Nakamura K, Kanno T, Niwano Y: Presence of hydrogen peroxide, a source of hydroxyl radicals, in acid electrolyzed water. PLoS ONE, 7(9):e46392, 2012

67. Nakamura K, Yamada Y, Takeda Y, Mokudai T, Ikai H, Inagaki R, Kanno T, Sasaki K, Kohno M, Niwano Y: Corrosive effect of hydroxyl radical generated by photolysis of H2O2 on dental metals. Dent Mater J, 31(6):941-946, 2012

68. Ishiyama K, Nakamura K, Ikai H, Kanno T, Kohno M, Sasaki K, Niwano Y: Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents. PLoS ONE, 7(5):e37871, 2012

69. Hayashi E, Mokudai T, Yamada Y, Nakamura K, Kanno T, Sasaki K, Niwano Y: In vitro and in vivo anti-Staphylococcus aureus activities of a new disinfection system utilizing photolysis of hydrogen peroxide. J Biosci Bioeng, 114(2):193-197, 2012

70. Ayaki M, Iwasawa A, Niwano Y: Cell viability score as an integrated indicator for cytotoxicity of benzalkonium chloride-containing antiglaucoma eyedrops. Biocontrol Sci, 17(3):121-128, 2012

71. Ayaki M, Iwasawa A, Niwano Y: Comparative study of in vitro ocular surface cytotoxicity for fixed combination of 0.5% timolol/1% dorzolamide eyedrop and its components with 0.005% benzalkonium chloride. Biocontrol Sci, 17(3):115-120, 2012

72. Yamada Y, Mokudai T, Nakamura K, Hayashi E, Kawana Y, Kanno T, Sasaki K, Niwano Y: Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats. J Toxicol Sci, 37(2):329-335, 2012

73. Ayaki M, Iwasawa A, Niwano Y: In vitro assessment of six topical antibiotics cytotoxicity to　four cultured ocular surface cell lines. Biocontrol Sci, 17(2):93-99, 2012

74. Kanno T, Nakamura K, Ikai H, Hayashi E, Shirato M, Mokudai T, Iwasawa A, Niwano Y, Kohno M, Sasaki K: Novel denture cleaning system based on hydroxyl radical disinfection. Int J Prosthodont, 25(4):376-380, 2012

75. Yaekashiwa N, Sato E, Nakamura K, Iwasawa A, Kudo A, Kanno T, Kohno M, Niwano Y: Determination of reactive oxygen species generated by phorbol 12-myristate 13-acetate-stimulated oral polymorphonuclear cells from healthy human volunteers without any dental problems. Arch Oral Biol, 57:636-641, 2012

76. Nakamura K, Kanno T, Mokudai T, Iwasawa A, Niwano Y, Kohno M: Microbial resistance in relation to catalase activity to oxidative stress induced by photolysis of H2O2. Microbiol Immunol, 56(1):48-55, 2012

77. Shirato M , Ikai H, Nakamura K, Hayashi E, Kanno T, Sasaki K, Kohno M, Niwano Y: Synergistic effect of thermal energy on bactericidal action of photolysis of H2O2 in relation to acceleration of hydroxyl radical generation, Antimicrob Agents Chemother, 56(1):295-301, 2012

78. Iwasawa A, Niwano Y, Kohno M, Ayaki M: Virucidal activity of alcohol-based hand rub disinfectants. Biocontrol Sci, 17(1):45-59, 2012

79. Kanno T, Nakamura K, Ikai H, Kikuchi K, Sasaki K, Niwano Y: Literature review of the role of hydroxyl radicals in chemically-induced mutagenicity and carcinogenicity for the risk assessment of a disinfection system utilizing photolysis of hydrogen peroxide. J Clin Biochem Nutr, 51(1):9-14, 2012

80. Iwasawa A, Niwano Y, Kohno M, Ayaki M: Bactericidal effects and cytotoxicity of new aromatic dialdehyde disinfectants (ortho-phthalaldehyde). Biocontrol Sci, 16(4):165-170, 2011

81. Ayaki M, Iwasawa A, Niwano Y: Cytotoxicity assays of new artificial tears containing 2-methacryloyloxyethyl phosphorylcholine polymer for ocular surface cells. Jpn J Ophthalmol, 55(5):541-546, 2011

82. Sato E, Mokudai T, Niwano Y, Kohno M: Kinetic analysis of reactive oxygen species generated by the in vitro reconstituted NADPH oxidase and xanthine oxidase systems. J Biochem, 150(2):173-181, 2011

83. Mokudai T, Kohno M, Niwano Y: Determination and speciation of vanadium(IV) and vanadium(V) in water sample by ion chromatography in combination with electron spin resonance analysis and/or electrolysis-induced reduction of vanadium(V). J Funct Water, 6(1):27-33, 2011

84. Kohno M, Mokudai T, Ozawa T, Niwano Y: Free radical formation from sonolysis of water in the presence of different gases. J Clin Biochem Nutr, 49(2):96-101, 2011

85. Nakamura K, Ishiyama K, Ikai H, Kanno T, Sasaki K, Niwano Y, Kohno M: Reevaluation of analytical methods for photogenerated singlet oxygen. J Clin Biochem Nutr, 49(2):87-95, 2011

86. Niwano Y, Saito K, Yoshizaki F, Kohno M, Ozawa T: Extensive screening for herbal extracts with potent antioxidant properties. J Clin Biochem Nutr, 48(1):78-84, 2011

87. Ikai H, Nakamura K, Shirato M, Kanno T, Iwasawa A, Sasaki K, Niwano Y, Kohno M: Photolysis of hydrogen peroxide, an effective disinfection system via hydroxyl radical formation. Antimicrob Agents Chemother, 54:5086-5091, 2010

88. Tada M, Kohno M, Kasai S, Niwano Y: Generation mechanism of radical species by tyrosine-tyrosinase reaction. J Clin Biochem Nutr, 47:162-166, 2010

89. Nakamura K, Kanno T, Ikai H, Sato E, Mokudai T, Niwano Y, Ozawa T, Kohno M: Reevaluation of quantitative ESR spin trapping analysis of hydroxyl radical by applying sonolysis of water as a model system. Bull Chem Soc Jpn, 83:1037-1046, 2010

90. Nakamura K, Kanno T, Mokudai T, Iwasawa A, Niwano Y, Kohno M: A novel analytical method to evaluate directly catalase activity of microorganisms and mammalian cells by ESR oximetry. Free Radic Res, 44:1036-1043, 2010

91. Kim D, Cha SH, Sato E, Niwano Y, Kohno M, Jiang Z, Yamasaki Y, Matsuyama Y, Yamaguchi K, Oda T: Evaluation of the potential biological toxicities of aqueous extracts from red tide phytoplankton cultures in in vitro and in vivo systems. J Toxicol Sci, 35:591-599, 2010

92. Nakashima T, Seki T, Matsumoto A, Miura H, Sato E, Niwano Y, Kohno M, Ōmura S, Takahashi Y: Generation of Reactive Oxygen Species from conventional laboratory media. J Biosci Bioeng, 110:304-307, 2010

93. Tada M, Kohno M, Niwano Y: Scavenging or quenching effect if melanin on superoxide an5ion and singlet oxygen. J Clin Biochem Nutr, 46:224-228, 2010

94. Beppu F, Niwano Y, Sato E, Kohno M, Tsukui T, Hosokawa M, Miyashita K: In Vitro and in vivo evaluation of mutagenicity of fucoxanthin and Its metabolite fucoxanthinol. J Toxicol Sci, 34:693-698, 2009

95. Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita K: Single and repeated oral dose toxicity study of fucoxanthin, a marine carotenoid, in mice. J Toxicol Sci, 34:501-510, 2009

96. Iwasawa A, Saito K, Mokudai T, Kohno M, Ozawa T, Niwano Y: Fungicidal action of hydroxyl radicals generated by ultrasound in water. J Clin Biochem Nutri, 45:214-218, 2009

97. Tada M, Ichiishi E, Saito R, Emoto N, Niwano Y, Kohno M: Myristic acid, a side chain of phorbol myristate acetate (PMA), can activate human polymorphonuclear leukocytes to produce oxygen radicals more potently than PMA. J Clin Biochem Nutr, 45:309-314, 2009

98. Iwasawa A, Saito K, Mokudai T, Kohno M, Ozawa T, Niwano Y: Fungicidal action of hydroxyl radicals generated by ultrasound in water. J Clin Biochem Nutr, 45:214-218, 2009

99. Iwasawa A, Niwano Y, Mokudai T, Kohno M: Antiviral activity of proanthocyanidin against feline calicivirus used as a surrogate for noroviruses, and coxsackievirus used as a representative enteric virus. Biocontrol Sci 14:107-111, 2009

100. Niwano Y, Beppu F, Shimada T, Kyan R, Yasura K, Tamaki M, Nishino M, Midorikawa Y, Hamada H: Extensive screening for plant foodstuffs in Okinawa, Japan with anti-obese activity on adipocytes in vitro. Plant Foods Hum Nutr, 64:6-10, 2009

101. Niwano Y, Adachi T, Kashimura J, Sakata T, Sasaki H, Sekine K, Yamamoto S, Yonekubo A, Kimura S: Is Glycemic Index of Food a Feasible Predictor of Appetite, Hunger, and Satiety? J Nutr Sci Vitaminol, 55:201-207, 2009

102. Kohno M, Sato E, Yaekashiwa N, Mokudai T, Niwano Y: Proposed Mechanisms for HOOOH Formation in Two Typical Enzyme Reactions Responsible for Superoxide Anion Production in Biological Systems. Chem Lett, 38:302-307, 2009

103. Saito K, Kohno M, Yoshizaki F, Niwano Y: Antioxidant properties of herbal extracts selected from screening for potent scavenging activity against superoxide anions. J Sci Food Agric, 88:2707-2712, 2008

104. Kohno M, Takeda M, Niwano Y, Saito R, Emoto N, Tada M, Kanazawa T, Ohuchi N, Yamada R: Early diagnosis of cancer by detecting the chemiluminescence of hematoporphyrins in peripheral blood lymphocytes. Tohoku J Exp Med, 216:47-52, 2008

105. Sato E, Mokudai T, Niwano Y, Kamibayashi M, Kohno M: Existence of a New Reactive Intermediate Oxygen Species in Hypoxanthine and Xanthine Oxidase Reaction. Chem Pharm Bull, 56:1194-1197, 2008

106. Nakashima T, Niwano Y, Takeshita S:Effects of antifungal agents on the red tide phytoplankton –possibility of a novel preventive tool- Aquaculture Res 39:1346-1350, 2008

107. Saito K, Kohno M, Yoshizaki F, Niwano Y: Extensive screening for edible herbal extracts with potent scavenging activity against superoxide anions. Plant Foods Hum Nutr, 63:65-70, 2008

108. Nakashima T, Iwashita T, Fujita T, Sato E, Niwano Y, Kohno M, Kuwahara S, Harada N, Takeshita S, Oda T: A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac. J Biochem, 143:107-115, 2008

109. Sato E, Kohno M, Nakashima T, Niwano Y: Ciclopirox olamine directly scavenges hydroxyl radical. Int J Dermatol, 47:15-18, 2008

110. Niwano Y, Mitsui G, Kohno M: Chemokines and their receptors as a target for the treatment of contact hypersensitivity. J Anti-Inflamm Anti-Allergy Agents Med Chem, 7:45-51, 2008

111. Sachindra NM, Sato E, Maeda H, Hosokawa M, Niwano Y, Kohno M, Miyashita K: Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin abd its metabolites. J Agric Food Chem, 55:8516-8522, 2007

112. Kim D, Nakashima T, Matsuyama Y, Niwano Y, Yamaguchi K, Oda T: Presence of the distinct systems responsible for superoxide anion and hydrogen peroxide generation in red tide phytoplankton Chatonella marina and Chatonella ovata. J Plankton Res29:241-247, 2007

113. Sato E, Niwano Y, Mokudai T, Kohno M, Matsuyama Y, Kim D, Oda T: A Discrepancy in Superoxide Scavenging Activity between the ESR-Spin Trapping Method and the Luminal Chemiluminescence Method. Biosci Biotechnol Biochem, 71:1505-1513, 2007

114. Niwano Y, Sato E, Kohno M, Matsuyama Y, Kim D, Oda T: Antioxidant Properties of the Aqueous Extracts from Red Tide Plankton Cultures. Biosci Biotechnol Biochem, 71:1145-1153, 2007

115. Sato E, Niwano Y, Matsuyama Y, Kim D, Nakashima T, Oda T, Kohno M: Some Dinophycean Red Tide Plankton Species Generate a Superoxide Scavenging Substance. Biosci Biotechnol Biochem, 71:704-710, 2007

116. Sato E, Kato M, Kohno M, Niwano Y: Clindamycin phosphate scavenges hydroxyl radical Int J Dermatol, 46:1185-1187, 2007

117. Nakashima T, Sato E, Niwano Y, Kohno M, Muraoka W, Oda T: Inhibitory or scavenging action of ketoconazole and ciclopirox olamine against reactive oxygen species released by primed inflammatory cells. Br J Dermatol, 156:720-727, 2007

118. Sato E, Kohno M, Niwano Y: Increased level of tetrahydro-β-carboline derivatives in short-term fermented garlic. Plant Foods Hum Nutr, 61:175-178, 2006

119. Sato E, Kohno M, Hamano H, Niwano Y: Increased anti-oxidative potency of garlic by spontaneous short-term fermentation. Plant Foods Hum Nutr, 61:157-160, 2006

120. Nishizawa M, Kohno M, Nishimura M, Kitagawa A, Niwano Y: Presence of peroxyradicals in cigarette smoke and the scavenging effect of shikonin, a naphthoquinone pigment. Chem Pharm Bull, 53:796-799, 2005

121. Nishizawa M, Kohno M, Nishimura M, Kitagawa A, Niwano Y: Non-reductive scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) by peroxyradical –A useful method for quantitative analysis of peroxyeradical-. Chem Pharm Bull, 53:714-716, 2005

122. Nimura K, Niwano Y, Ishizuka S, Fukumoto R: Actin gene-targeted RT-PCR could be a useful method for evaluating fungicidal activity against dermatophyte in vitro. J Int Med Res, 31:407-412, 2003

123. Mitsui G, Mitsui K, Hirano T, Ohara O, Kato M, Niwano Y: Kinetic profiles of sequential expressions for chemokine genes in mice with contact hypersensitivity. Immunol Lett, 86:191-197, 2003

124. Niwano Y, Ohmi T, Seo A, Kodama H, Koga H, Sakai A: Lanoconazole and its related optically active compound NND-502: Novel antifungal imidazoles with a ketene dithioacetal structure. Curr Med Chem–Anti-Infect Agents-, 2:147-160, 2003

125. Nimura K, Niwano Y, Ishizuka S, Fukumoto R: Comparison of in vitro antifungal activities of topical antimycotics launched in 1990’s in Japan. Int J Antimicrob Agents, 18(2):173-178, 2001

126. Niwano Y, Koga H, Kodama H, Kanai K, Miyazaki T, Yamaguchi H: Inhibition of sterol 14α-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent. Med Mycol, 37:351-355, 1999

127. Niwano Y, Kuzuhara N, Goto Y, Munechika Y, Kanai K, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections. Int J Antimicrob Agents, 12:221-228, 1999

128. Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND- 502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother, 42:967-970, 1998

129. Niwano Y, Koga H, Sakai A, Kanai K, Hamaguchi H, Uchida M, Tachikawa T: Wound healing effect of malotilate in rats. Arzneim Forsch/Drug Res, 46:450-455, 1996

130. Niwano Y, Koga H, Kanai K, Hamaguchi H, Uchida M, Yamaguchi H: Wound healing effect of the new imidazole antimycotic lanoconazole in rats. Arzneim Forsch/Drug Res, 46:218-223, 1996

131. Niwano Y, Tabuchi T, Kanai K, Hamaguchi H, Uchida K, Yamaguchi H: Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent. Antimicrob Agents Chemother, 39:2353-2355, 1995

132. Niwano Y, Seo A, Kanai K, Hamaguchi H, Uchida K, Yamaguchi H: Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs. Antimicrob Agents Chemother, 38:2204-2206, 1994

133. Niwano Y, Hainen WB, Becker BA, Johnson HD: Suppressed lymphocyte blastogenesis in newborn goats subjected to maternal separation. Jpn J Zootech Sci, 61:1127-1130, 1990

134. Niwano Y, Becker BA, Mitra R, Caldwell CW, Abdalla EB, Johnson HD: Suppressed peripheral blood lymphocyte blastogenesis in pre- and post-partal sheep by chronic heat-stress, and suppressive property of heat-stressed sheep serum on lymphocytes. Dev Com Immunol, 14:139-149, 1990

135. Niwano Y, Hansen TR, Kazemi M, Malathy PV, Johnson HD, Roberts RM, Imakawa K: Suppression of T-lymphocyte blastogenesis by ovine trophoblast protein-1 and human interferonα may be independent of interleukin-2 production. Am J Reprod Immunol, 20:21-26, 1989

136. Niwano Y, Konaka S, Uchida M, Sugimoto T: Activation of　mitochondrial functions by malotilate in relation to accelerated liver regeneration in partially hepatectomized rats. Jpn J Pharmacol, 42:525-529, 1986

137. Niwano Y, Katoh M, Uchida M, Sugimoto T: Acceleration of liver regeneration by malotilate in partially hepatectomized rats. Jpn J Pharmacol, 40:411-415, 1986

138. Niwano Y, Ishii T, Ishibashi T: Effect of pinealectomy on the porphyrin content of the Harderian gland in rats. Jpn J Zootech Sci, 55:894-896, 1984